When you kill monsters you have a chance to obtain different Runes that is automatically placed in your stash (Depot).

Enchanting Rune - Can be used on a piece of equipment to add random enchant.

Alteration Rune - Can be used on a piece of equipment to remove last enchant.

Upgrade Rune - Can be used on a piece of equipment for a chance to upgrade it.

Fortune Rune - Can be used on a piece of equipment to change values of the last rolled enchant.

Faith Rune - Can be used on a piece of equipment to change values of all enchants.

Magnet Rune - Can be used on a piece of equipment to remove all enchants.

Soul Rune - Can be used on a piece of equipment to increase Item Level, decreases on failed attempt.

Annulment Rune - Can be used on a piece of equipment to remove random enchant.

Corrupted Rune - Corrupts an item, modifying it unpredictably. Corrupted items cannot be modified again.

Ancient Rune - Can be used on a piece of equipment to fill it with random enchants.

Harvest Rune - Extracts attributes from selected item and stores them in this rune, can be then used on a different item of the exact same type to apply these attributes.

Limitless Rune - Can be used on an item to remove the item level requirement.

Mirror Rune - Makes a copy of an item with every value being the same, mirrored items can't be modified.

To level up, gain experience points by completing quests and defeating enemies.

To be continued..